Compounds and methods for the detection of TRPV-6 cancers and drug delivery
AssigneeSoricimed Biopharma Inc.
InventorJohn M. Stewart
Life of this patent
Estimating the term…
Abstract
Compounds containing TRPV6-binding peptides and their use in the detection and diagnosis of cancer are described. Also described are methods for detecting and staging cancer that use the compounds of the invention. Compounds containing TRPV6-binding peptides are useful for the delivery of diagnostic and therapeutic agents to cells or tumors that express TRPV6.
Claims8
A method for the treatment of cancer by delivering a biomolecule to a cell expressing Transient Receptor Potential Vanilloid 6 (TRPV6), comprising contacting the cell in vivo with a compound comprising a TRPV6-binding peptide conjugated to the biomolecule, wherein the biomolecule is an anti-cancer agent, and wherein the TRPV6-binding peptide:
- a) comprises from 9 to 27 contiguous C-terminal amino acids of SEQ ID NO:1;
- b) has an amino acid sequence with at least 90% identity to HPSKVDLPR (SEQ ID NO:
- 3);
- c) has an amino acid sequence with at least 90% identity to KEFLHPSKVDLPR (SEQ ID NO:
- 4);
- or
- d) has an amino acid sequence with at least 90% identity to
- (SEQ ID NO:
- 1)
- EGKLSSNDTEGGLCKEFLHPSKVDLPR.
Dependencies are inferred from the claim text.