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US 12,458,606 B2Granted
Polymer nanoparticle compositions for in vivo expression of polypeptides
AssigneeBattelle Memorial Institute
InventorsAnthony D. Duong, Kenneth R. Sims, Jr., Cherry Gupta, Danielle J. Huk, Michael Riedl, Andrea D. McCue, Michael Wagner, Julianne N.P. Smith, Jacqueline Grible
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Abstract
The disclosure relates to block copolymer nanoparticles for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering nucleotides that encode polypeptides.
Claims8
A block copolymer comprising a first block and a second block, wherein
- (i) the first block comprises poly-2-(dimethylamino)ethyl methacrylate (DMAEMA);
- and
- (ii) the second block comprises a copolymer of butylmethacrylate (BMA) and vinylmethacrylate (VMA).
Dependencies are inferred from the claim text.