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US 12,458,601 B2Granted
Tamper-resistant drug dosage forms and methods of making and use thereof
AssigneeTemple University of the Commonwealth System of Higher Education
InventorReza A. Fassihi
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Abstract
A tamper resistant drug dosage is described. The drug dosage form includes a matrix polymer, a scaffold polymer, and a therapeutic agent, and the porosity of the drug dosage form is less than 10%. Methods for making and using the tamper resistant drug dosage forms are described.
Claims8
A drug dosage form comprising:
- a matrix polymer selected from the group consisting of polypropylene oxide, polyethylene oxide, polymethylene oxide, and mixtures, co-polymers, block co-polymers thereof;
- a scaffold polymer comprising polyvinylpyrrolidone and polyvinyl acetate;
- and
- a therapeutic agent;
- wherein the mass ratio of matrix polymer to scaffold polymer is about 4:1 to 3:1;
- and
- wherein the porosity of the drug dosage form is less than about 10%.
4 more elements
Dependencies are inferred from the claim text.