Carboxylic acid loaded salt carrier and the method for producing thereof
OwnerLucas Brendler, Andre Brendlerinventors
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Abstract
A solid compound prepared as a powder that exhibits good flowability and having a specific structure is provided. The solid compound contains a carrier carboxylic acid salt and a loaded carboxylic acid, wherein the pKa of the corresponding carboxylic acid of the carrier carboxylic acid is lower than or equal to the pKa of the loaded carboxylic. The loaded carboxylic acid is physisorbed within the structure of the carrier carboxylic acid salt, and wherein the water content of the solid compound is less than 2 equivalents of water relative to the carrier carboxylic acid. Processes and pharmaceutical compositions containing the solid compound are also provided.
Claims12
A solid compound prepared as a powder that exhibits good flowability, the solid compound comprising a following structure,
- a carrier carboxylic acid salt (M2+)1+m(R1COO)2(m+1)−in which
- M2+ is an alkaline earth metal ion or a divalent metal ion selected from the group consisting of iron (Fe), copper (Cu), zinc (Zn), manganese (Mn), tin (Sn), lead (Pb), and nickel (Ni), or a mixture of thereof,
- R1 is an optionally substituted C1-C10-alkyl group, an optionally substituted mono- or polyunsaturated C1-C10-alkyl group, or an optionally substituted aryl group, wherein the substituents are selected from the group consisting of carbonyl group (═O), carboxylic acid group (—COOH), amino group (—NH2), hydroxy group (—OH), halogen, cyano group (—CN), and a mixture thereof, and
- wherein m is 0 to 2,
- a loaded carboxylic acid R2COOH,
- wherein R2 is an optionally substituted C1-C10-alkyl group or an optionally substituted mono- or polyunsaturated C1-C10-alkyl group, wherein the substituents, if present, are selected from the group consisting of carbonyl group (═O), carboxylic acid group (COOH), amino group (—NH2), hydroxy group (—OH), halogen or cyano group (CN) or a mixture thereof, and
- wherein 2≤n≤10;
- wherein
- a pKa1 of a corresponding carboxylic acid of the carrier carboxylic acid (R1COO)(m+1)−≤pKa1 of the loaded carboxylic acid(s) R2COOH,
- wherein the loaded carboxylic acid(s) R2COOH is physisorbed within a structure of the carrier carboxylic acid salt (M2+)1+m(R1COO)2(m+1)−,
- wherein a water content of the solid compound is less than 2 equivalents of water relative to the carrier carboxylic acid salt;
- wherein (R1COO)(m+1)− comprises a carrier carboxylic acid selected from the group consisting of formate, acetate, glycolate, propionate, butyrate, succinate, fumarate, maleate, adipate, malate, malonate, tartrate, aspartate, glutamate, benzoate, salicylate, and ascorbate.
Dependencies are inferred from the claim text.