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US 12,458,568 B2Granted
Coaxial nozzle configuration and methods thereof
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsYong Huang, Yifei Jin
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Abstract
Embodiments of the present disclosure provide for coaxial nozzles, capsule fabrication systems comprising coaxial nozzles, and methods of capsule fabrication using capsule fabrication systems. In certain embodiments, coaxial nozzle configurations, capsule fabrication systems, and methods as described herein can be used for multi-layered capsule fabrication.
Claims20
A method for capsule fabrication, the method comprising:
- providing a capsule fabrication system, wherein the capsule fabrication system comprises:
- a coaxial nozzle comprising a core channel, an annular channel, and a sheath channel, the coaxial nozzle configured to form a compound flow of at least one fluid, wherein the annular channel and the sheath channel are configured to achieve uniform flow velocity distribution of fluid flow at an annular channel outlet and a sheath channel outlet of the coaxial nozzle,
- wherein the annular channel has a diameter of about 8.5 mm, a first length of between about 2.0 mm and about 4.0 mm, a second length of between about 12.5 mm and about 13.0 mm, and a height between about 2.0 mm and about 2.5 mm, and
- wherein the sheath channel has a length between about 1.5 mm and about 2.0 mm, a first diameter between about 14.0 mm and about 16.0 mm, a second diameter between about 11.0 mm and about 13.0 mm, and a height between about 8.0 mm and about 8.6 mm, the capsule fabrication system further comprising:
- a fluid delivery system configured to deliver a first fluid of the at least one fluid to the core channel, a second fluid of the at least one fluid to the annular channel, and a third fluid of the at least one fluid to the sheath channel, wherein the compound flow comprises at least one of:
- a core flow of the first fluid, an annular flow of the second fluid, and a sheath flow of the third fluid;
- and
- a vibrator configured to introduce vibrations to the compound flow, the method further comprising:
- initiating capsule fabrication by delivering fluid to one or more of the core channel, the annular channel, and the sheath channel of the capsule fabrication system;
- forming the compound flow from the at least one fluid delivered to the one or more of the of the core channel, the annular channel, and the sheath channel, wherein the compound flow comprises one or more of the core flow, the annular flow, and the sheath flow;
- and
- introducing a vibration, using the vibrator, to the compound flow, thereby developing one or more capsules.
9 more elements
A method for capsule fabrication, the method comprising:
- providing a capsule fabrication system, the capsule fabrication system comprising:
- a coaxial nozzle, wherein the coaxial nozzle comprises a core channel, an annular channel, and a sheath channel, and wherein the coaxial nozzle is configured to output one or more capsules, wherein the coaxial nozzle is dimensioned and configured to achieve uniform flow velocity distribution of fluid flow at an annular channel outlet and a sheath channel outlet of the coaxial nozzle,
- wherein the annular channel has a diameter of about 8.5 mm, a first length of between about 2.0 mm and about 4.0 mm, a second length of between about 12.5 mm and about 13.0 mm, and a height between about 2.0 mm and about 2.5 mm, and
- wherein the sheath channel has a length between about 1.5 mm and about 2.0 mm, a first diameter between about 14.0 mm and about 16.0 mm, a second diameter between about 11.0 mm and about 13.0 mm, and a height between about 8.0 mm and about 8.6 mm, the method further comprising:
- initiating capsule fabrication by delivering fluid to one or more of the core channel, the annular channel, or the sheath channel of the capsule fabrication system;
- forming a compound flow from the at least one fluid delivered to the one or more if the core channel, the annular channel, and the sheath channel, wherein the compound flow comprises one or more of a core flow of a first fluid, an annular flow of a second fluid, and a sheath flow of a third fluid;
- and
- introducing a vibration to the compound flow, thereby causing development of the one or more capsules in air after being communicated out of the coaxial nozzle.
5 more elements
Dependencies are inferred from the claim text.