System and method for magnetic resonance neurography using intravenous ultrasmall supraparamagnetic iron oxide particles
AssigneeNew York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery
InventorsDarryl B. Sneag, Ek Tsoon Tan
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Abstract
Some implementations provide a method for imaging one or more peripheral nerves in a region of a subject, which method includes: introducing a dose of an iron-based agent into the subject, wherein the dose causes a reduction of a T2 relaxation time of the subject's blood; and acquiring, from a magnetic resonance imaging (MRI) scanner, one or more fluid-sensitive MRI images of the region of the subject that has received the dose. The magnetic resonance (MR) signals from the subjects blood in the region is substantially reduced in response to the dose of the iron-based agent.
Claims18
A method for imaging one or more peripheral nerves in an anatomical region of a subject, which method comprises:
- introducing into a subject a dose of an iron-based contrast agent sufficient to cause a reduction of a T2 relaxation time of the subject's blood;
- and
- acquiring, from a magnetic resonance imaging (MRI) scanner, one or more MRI images of the anatomical region of the subject that includes the one or more peripheral nerves and at least one vessel, wherein the anatomical region has been impacted by the dose of the iron-based contrast agent, wherein the one or more MRI images are more sensitive to mobile water molecules than immobile water molecules, and wherein the one or more MRI images delineate the one or more peripheral nerves more conspicuously than the subject's blood contained in the at least one vessel adjacent to the one or more peripheral nerves.
Dependencies are inferred from the claim text.