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US 12,456,543 B2Granted
Enzymes
AssigneeUniversity Court of the University of St Andrews
InventorsRebecca Goss, Danai-Stella Gkotsi
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Abstract
The present disclosure is based on the identification of a novel sequence motif present in halogenase type enzymes. From this, the disclosure provides methods for identifying and or detecting halogenases (halogenating enzymes) and novel halogenases identifiable using such methods. The disclosure also provides a novel cohort of enzymes and novel methods for achieving substrate halogenation.
Claims5
A method of identifying or detecting amino acid sequences which encode or provide halogenases, said method comprising:
- (i) probing or screening a candidate amino acid sequence for the presence of:
- (SEQ ID NO:
- 1)
- Fx•Px•Sx•G,
- wherein “x” is any amino acid and each “⋅” represents independently the number of x residues (“x's”) between each conserved residue, and
- (ii) subjecting an amino acid sequence identified in step (i) to comprise SEQ ID NO:
- 1 to an assay to determine the level or presence of halogenase activity.
4 more elements
Dependencies are inferred from the claim text.