Time delay integration acquisition for spatial genomics imaging
AssigneeApplied Materials, Inc.
InventorsJoseph R. Johnson, Ang Li, Jean Marc Fan Chung Tsang Min Ching, Mehdi Vaez-Iravani
Life of this patent
Estimating the term…
Abstract
An imaging system for capturing spatial-omic images of biological tissue samples may include an imaging chamber configured to secure a biological tissue sample placed in the imaging system; a Time Delay and Integration (TDI) imager comprising at least one scan line; a light source configured to illuminate an area on the biological tissue sample that is being captured by the TDI imager; and a controller configured to cause the TDI imager to scan the biological tissue sample using one or more TDI scans of the biological tissue sample.
Claims18
An imaging system for capturing spatial-omic images of biological tissue samples, the imaging system comprising:
- an imaging chamber configured to secure a biological tissue sample placed in the imaging system;
- a Time Delay and Integration (TDI) imager comprising a plurality of scan lines;
- a light source and a fiber optic bundle comprising a plurality of fiber-optic lines, wherein each of the plurality of fiber-optic lines is configured to deliver light of different wavelengths to illuminate an area on the biological tissue sample that is being captured by a set of corresponding scan lines of the TDI imager;
- and
- a controller configured to cause the TDI imager to scan the biological tissue sample using one or more TDI scans of the biological tissue sample.
A method of capturing spatial-omic images of a biological tissue sample, the method comprising:
- securing a biological tissue sample in an imaging chamber of an imaging system;
- directing light from a light source through a fiber-optic bundle comprising a plurality of fiber-optic lines, wherein each of the plurality of fiber-optic lines is configured to deliver light of different wavelengths to illuminate an area on the biological tissue sample;
- and
- causing a Time Delay and Integration (TDI) imager to scan the biological tissue sample where the biological tissue sample is illuminated in individual areas corresponding to each of the plurality of fiber-optic lines that are captured by corresponding sets of scan lines of the TDI imager using one or more TDI scans of the biological tissue sample.
An imaging system for capturing spatial-omic images of biological tissue samples, the imaging system comprising:
- an imaging chamber configured to secure a biological tissue sample placed in the imaging system;
- a Time Delay and Integration (TDI) imager;
- a light source configured to illuminate areas on the biological tissue, each area being simultaneously illuminated with a distinct wavelength;
- and
- a controller configured to cause the TDI imager to simultaneously capture a plurality of distinct images of the biological tissue sample, wherein each of the plurality of distinct images corresponds to one of the plurality of distinct wavelengths captured by a corresponding set of scan lines of the TDI imager.
Dependencies are inferred from the claim text.