Process for the preparation of 2,4- or 2,5-pyridinedicarboxylic acid and copolymers derived therefrom
AssigneeBiome Bioplastics Limited
InventorsPaul Law, Paul Mines, Timothy Bugg
Life of this patent
Estimating the term…
Abstract
The present invention relates to processes for the formation of pyridinedicarboxylic acid (PDCA), in particular, 2,4-pyridinedicarboxylic acid (2,4-PDCA) and 2,5-pyridinedicarboxylic acid (2,5-PDCA), and mono- and diester derivatives thereof, from 3,4-dihydroxybenzoic acid, via a biocatalytic reaction using, for example, a protocatechuate dioxygenase such as protocatechuate 4,5-dioxygenase or protocatechuate 2,3-dioxygenase, and a nitrogen source. The invention also relates to copolymers that comprise the pyridinedicarboxylic acid monomers and derivatives thereof, processes for the formation of the copolymers and uses for the copolymers.
Claims11
A process comprising combining:
- (A) lignin, lignocellulose, vanillic acid and/or vanillin;
- and
- (B) bacteria modified to express protocatechuate 2,3-dioxygenase, wherein the bacteria comprise a praA gene that encodes the protocatechuate 2,3-dioxygenase;
- to produce 2,5-pyridinedicarboxylic acid.
A method comprising combining:
- (A) lignin, lignocellulose, vanillic acid and/or vanillin;
- and
- (B) protocatechuate 2,3-dioxygenase;
- to produce 2,5-pyridinedicarboxylic acid,
- wherein the method further comprises combining:
- (C) said pyridinedicarboxylic acid and/or a mono- or diester thereof;
- (D) at least one diol;
- and
- (E) optionally, at least one aliphatic dicarboxylic acid or a mono- or diester derivative thereof, to produce a copolymer comprising residues of (C), (D) and optionally (E);
- wherein the protocatechuate dioxygenase is produced by a bacteria modified to comprise a gene encoding the protocatechuate 2,3-dioxygenase, wherein the gene encoding the protocatechuate 2,3-dioxygenase is praA.
Dependencies are inferred from the claim text.