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US 12,454,560 B2Granted
Colon and pancreas cancer peptidomimetics
AssigneePrecision Biologics, Inc.
InventorXue-Ping Wang
Life of this patent
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Abstract
The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods.
Claims8
A method of producing an antibody that binds to an MUC5AC epitope which comprises a polypeptide which is at least 80% identical to the amino acid sequence of FPEDYFRYTNQK (SEQ ID NO:
- 4);
- SLPDDWFRYINY (SEQ ID NO:
- 5);
- SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 20, or SEQ ID NO:
- 24;
- which method comprises
- (i) immunizing a non-human animal with a polypeptide which comprises a polypeptide which is at least 80% identical to the amino acid sequence of FPEDYFRYTNQK (SEQ ID NO:
- 4;
- SLPDDWFRYINY (SEQ ID NO:
- 5);
- SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 20, or SEQ ID NO:
- 24;
- and
- (ii) selecting for one or more antibodies which specifically bind to said polypeptide.
17 more elements
Dependencies are inferred from the claim text.