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US 12,454,553 B2Granted
Antigenic multimeric respiratory syncytial virus polypeptides
AssigneeSanofi
InventorsKurt Swanson, Chih-Jen Wei, Gary J. Nabel
Life of this patent
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Abstract
This disclosure relates to antigenic multimeric respiratory syncytial virus (RSV) G polypeptides for use in eliciting an immune response to RSV.
Claims15
An antigenic RSV G polypeptide comprising more than two RSV G central conserved region (Gcc) monomers and a multimerization domain,
- wherein the polypeptide does not comprise ferritin and/or the polypeptide is a single chain polypeptide,
- wherein the more than two RSV Gcc monomers comprise RSV Gcc monomers of strain A and strain B,
- wherein the RSV Gcc of strain A comprises:
- a) the same sequence of amino acids as amino acids 2-42 of SEQ ID NO:
- 4, or
- b) the same sequence of amino acids as amino acids 151-193 of SEQ ID NO:
- 1;
- wherein the RSV Gcc of strain B comprises the same sequence of amino acids as amino acids 10-51 of SEQ ID NO:
- 8;
- and
- wherein the multimerization domain comprises the sequence of SEQ ID NOs:
- 9, 11, or 13.
9 more elements
An antigenic RSV G polypeptide comprising an amino acid sequence with at least 80% identity to any one of SEQ ID NOs:
- 4-8.
An antigenic RSV G polypeptide comprising an amino acid sequence with at least 80% identity to SEQ ID NO:
- 14.
Dependencies are inferred from the claim text.