Steroidal compositions and methods of treating lipogenic cancers

A compound of Formula IIa or a stereoisomer or pharmaceutically acceptable salt thereof:

• wherein:
• R6 is R6C (wherein * is the point of attachment to formula I):
• Q is absent or is O;
• n is selected from 0, 1, 2, and 3;
• p is selected from 0, 1, 2, and 3, provided that in R6C, when Q is absent, then n+p total at least 2;
• Het(Ar) is selected from the group pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, 1,2-thiazolyl, 1,3-thiazolyl, 1,2,5-thiadiazolyl, and 1,3-oxazolyl,
• (a) the Het(Ar) ring is optionally substituted with 1-2 groups selected from —NC, C1-6 alkyl, —C0-4 alkylene-C3-6 cycloalkyl, halo, CH2CF3, CHF2, CF3, CH2CHF2, C(OR)(CF3)2, C2-6 alkenyl, C2-6 alkynyl, —C0-4 alkylene-OR, —O—C2-4 alkylene-OR, —C0-4 alkylene-C(O)R, —C0-4 alkylene-C(O)OR, —C0-4 alkylene-C(O)NRaRb, —C0-4 alkylene-S(O)2NRaRb, —C0-4 alkylene-NRaC(O)—C1-4 alkyl, —C0-4 alkylene-NRaS(O)2—C1-4 alkyl, and —C0-4 alkylene-S(O)2—C1-4 alkyl;
• and,
• (b) R is C1-4 alkyl.