Pyrazole derivatives

A compound of formula (E)

• wherein:
• ring A as is a di- or tri-substituted pyrazole, substituted on one ring nitrogen by RB2 and substituted on at least one ring carbon by RB3;
• RB2 is C1-C3 alkyl or C1-C3fluoroalkyl;
• n is an integer of 1 or 2,
• each RB3 is independently halogen, C1-C3fluoroalkyl, C1-C3haloalkoxy, C1-C3alkoxy, C1-C3haloalkyl, or C1-C3alkyl;
• and
• R1 is C1-C6 alkyl, C2-C6alkenyl, C3-C6cyloalkyl, C3-C6cylcoalkenyl, optionally substituted phenyl, optionally substituted C5-C6 heteroaryl, —CR12R13, or —(O)R12;
• R12 is hydrogen, OH, C1-C3 alkoxy, or C1-C4 alkyl;
• and R13 is —C(O) NH2;
• or
• a compound of formula (H)
• wherein:
• ring A as is a di- or tri-substituted pyrazole, substituted on one ring nitrogen by RB2 and substituted on at least one ring carbon by RB3;
• RB2 is C1-C3 alkyl or C1-C3fluoroalkyl;
• n is an integer of 1 or 2,
• each RB3 is independently halogen, C1-C3fluoroalkyl, C1-C3haloalkoxy, C1-C3alkoxy, C1-C3haloalkyl, or C1-C3alkyl;
• and
• R1 is C1-C6 alkyl, C2-C6alkenyl, C3-C6cyloalkyl, C3-C6cylcoalkenyl, optionally substituted phenyl, optionally substituted C5-C6 heteroaryl, —CR12R13, or —C(O)R12,
• R12 is hydrogen, OH, C1-C3 alkoxy, or C1-C4 alkyl;
• and R13 is —C(O) NH2;
• R2 is hydrogen, C1-C6alkyl, —CralkoxyCsalkyl, C1-C6haloalkyl, —CralkoxyCshaloalkyl, C2-C6alkenyl, C2-C6alkynyl, or —(CR21R22)tR20,
• wherein each R20 is independently —C(O)OR23, —OC(O)R23, —C3-C6cycloalkyl, or an -aryl, -aryloxy, -heteroaryl, -heteroaryloxy or -heterocyclyl ring, wherein said ring is optionally substituted by 1 to 3 independent R25;
• r is an integer of 1, 2, 3, 4, or 5, s is an integer of 1, 2, 3, 4, or 5, and the sum of r+s is less than or equal to 6;
• t is an integer of 0, 1, 2, 3, 4, 5 or 6, each R21 is independently hydrogen or C1-C2 alkyl;
• each R22 is independently hydrogen or C1-C2 alkyl;
• R23 is hydrogen or C1-C4alkyl;
• and each R25 is independently halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, cyano, nitro, C1-C6alkylthio, C1-C6alkylsulphinyl, or C1-C6alkylsulphonyl;
• or
• a compound of formula (J)
• wherein:
• ring A as is a di- or tri-substituted pyrazole, substituted on one ring nitrogen by RB2 and substituted on at least one ring carbon by RB3;
• RB2 is C1-C3 alkyl or C1-C3fluoroalkyl;
• n is an integer of 1 or 2,
• each RB3 is independently halogen, C1-C3fluoroalkyl, C1-C3haloalkoxy, C1-C3alkoxy, C1-C3haloalkyl, or C1-C3alkyl;
• and
• R1 is C1-C6 alkyl, C2-C6alkenyl, C3-C6cyloalkyl, C3-C6cylcoalkenyl, optionally substituted phenyl, optionally substituted C5-C6 heteroaryl, —CR12R13, or —C(O)R12;
• R12 is hydrogen, OH, C1-C3 alkoxy, or C1-C4 alkyl;
• and R13 is —C(O) NH2,
• wherein the compound of formula (J) is not
• or
• a compound of formula (D)
• wherein:
• ring A as is a di- or tri-substituted pyrazole, substituted on one ring nitrogen by RB2 and substituted on at least one ring carbon by RB3;
• RB2 is C1-C3 alkyl or C1-C3fluoroalkyl;
• n is an integer of 1 or 2,
• each RB3 is independently halogen, C1-C3fluoroalkyl, C1-C3haloalkoxy, C1-C3alkoxy, C1-C3haloalkyl, or C1-C3alkyl;
• and
• R1 is C1-C6 alkyl, C2-C6alkenyl, C3-C6cyloalkyl, C3-C6cylcoalkenyl, optionally substituted phenyl, optionally substituted C5-C6 heteroaryl, —CR12R13, or —C(O)R12;
• R12 is hydrogen, OH, C1-C3 alkoxy, or C1-C4 alkyl;
• and R13 is —C(O) NH2.