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US 12,454,501 B2Granted
Evolving random heteropolymers towards catalytically active materials
AssigneeMassachusetts Institute of Technology
InventorsAlfredo Alexander-Katz, Shayna Hilburg, Ting Xu, Hao Yu, Stefan Marco Eres, Philjun Kang
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Abstract
The present disclosure relates to using monomer-based heteropolymers to create random heteropolymers that act as biomimetic catalysts that can be evolved to mimic activities of different classes of natural enzymes. The random heteropolymers comprise a mixture of heteropolymer sequences wherein a portion of the heteropolymers comprise a catalytically active region similar to that of a naturally occurring enzyme active site.
Claims19
A composition of biomimetic catalyst molecules comprising:
- a mixture of heteropolymer sequences wherein a portion of the heteropolymers comprise a catalytically active region similar to that of a naturally occurring enzyme active site, wherein the catalytically active region catalyzes a reaction of a substrate in a manner functionally similar to that of a naturally occurring enzyme;
- and
- wherein the portion of heteropolymers comprises a 3-dimensional configuration that mimics physicochemical properties of naturally occurring enzymes.
A biomimetic catalyst molecule comprising:
- a heteropolymer sequence comprising a catalytically active region similar to that of a naturally occurring enzyme active site, wherein the catalytically active region catalyzes a reaction of a substrate in a manner functionally similar to that of a naturally occurring enzyme;
- and
- wherein the sequence comprises a 3-dimensional configuration of a naturally occurring protein structure.
Dependencies are inferred from the claim text.