Incremental dose finding in controlled-release PTH compounds

A method of treating a patient having hypoparathyroidism, with parathyroid hormone (PTH), wherein the method comprises the step of administering a pharmaceutical composition comprising a controlled-release PTH compound to the patient in accordance with a dosage regimen in which dose adjustment in response to hypocalcemia or hypercalcemia is performed in increments of no more than 25%;

• wherein the controlled-release PTH compound is of formula (Ia) or a pharmaceutically acceptable salt thereof:
• Z-(L2-L1-D)x (Ia);
• wherein —Z comprises a branched PEG polymer with a molecular weight of about 40 kDa,
• -L2-L1- has the formula:
• wherein the unmarked dashed line indicates attachment by an amide bond to a nitrogen of
• -D, and the dashed line marked with an asterisk indicates attachment to —Z, wherein -D is PTH (1-34) (SEQ ID NO:
• 51) and x is 1.