Development of mosaic vaccines against foot and mouth disease virus serotype O
AssigneesThe United States of America as represented by the Secretary of Agriculture, Kansas State University Research Foundation, Triad National Security, LLC
InventorsAida E. Rieder, Katherine M. Pflaum, Fayna C. Diaz San Segundo, William M. Fischer, Tatjana Sitt
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Abstract
Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype O FMDV strains.
Claims12
A synthetic polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, SEQ ID NO:
- 4, SEQ ID NO:
- 6, SEQ ID NO:
- 8, or SEQ ID NO:
- 10.
A recombinant foot-and-mouth disease virus (FMDV) comprising a synthetic polypeptide having the amino acid sequence of SEQ ID NO:
- 2, SEQ ID NO:
- 4, SEQ ID NO:
- 6, SEQ ID NO:
- 8, or SEQ ID NO:
- 10.
A method of eliciting an immune response against serotype O foot-and-mouth disease virus (FMDV) in a subject, comprising administering to the subject a composition comprising a synthetic polypeptide having the amino acid sequence of SEQ ID NO:
- 2, SEQ ID NO:
- 4, SEQ ID NO:
- 6, SEQ ID NO:
- 8, or SEQ ID NO:
- 10, thereby eliciting an immune response to serotype O FMDV.
Dependencies are inferred from the claim text.