Complex comprising a cell penetrating peptide, a cargo and a TLR peptide agonist for treatment of glioblastoma
AssigneeAmal Therapeutics SA
InventorsMadiha Derouazi, Elodie Belnoue
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Abstract
The present invention provides a novel complex for use in the prevention and/or treatment of glioma, in particular glioblastoma, the complex comprising a) a cell penetrating peptide, b) at least one antigen or antigenic epitope, and c) at least one TLR peptide agonist, wherein the components a)-c) are covalently linked. In particular, compositions for use in the prevention and/or treatment of glioma, in particular glioblastoma, such as a pharmaceutical compositions and vaccines are provided.
Claims26
A method for treating glioma in a subject in need thereof, the method comprising administering to the subject a complex comprising:
- a) a cell penetrating peptide having an amino acid sequence consisting of SEQ ID NO:
- 6 (CPP/Z13);
- b) at least one antigen or antigenic epitope, wherein the at least one antigen or antigenic epitope comprises at least one tumor epitope;
- and
- c) at least one TLR peptide agonist, wherein the TLR peptide agonist is a TLR2 or TLR4 peptide agonist, having an amino acid sequence consisting of SEQ ID NO:
- 15,
- wherein the components a)-c) are covalently linked.
A method for treating glioma in a subject in need thereof, the method comprising administering to the subject a complex comprising:
- a) a cell penetrating peptide, having an amino acid sequence consisting of SEQ ID NO:
- 6 (CPP/Z13);
- b) at least one antigen or antigenic epitope, wherein the at least one antigen or antigenic epitope comprises at least one tumor epitope;
- and
- c) at least one TLR peptide agonist, wherein the TLR peptide agonist is a TLR2 or TLR4 peptide agonist, having an amino acid sequence consisting of SEQ ID NO:
- 15,
- wherein the components a)-c) are covalently linked, and
- wherein the complex is a recombinant polypeptide or a recombinant protein.
A method for treating glioma in a subject in need thereof, the method comprising administering to the subject a complex consisting of:
- a) a cell penetrating peptide having an amino acid sequence consisting of SEQ ID NO:
- 6 (CPP/Z13);
- b) at least one antigen or antigenic epitope, wherein the at least one antigen or antigenic epitope comprises at least one tumor epitope;
- c) at least one TLR peptide agonist, wherein the TLR peptide agonist is a TLR2 or TLR4 peptide agonist, having an amino acid sequence consisting of SEQ ID NO:
- 15,
- wherein the components a)-c) are covalently linked, and
- wherein the complex is a recombinant polypeptide or a recombinant protein.
Dependencies are inferred from the claim text.