Gas-generating micelle for reducing localized fat
AssigneeSupernova Bio Co., Ltd.
InventorsKuen Yong Lee, Choong Gu Kim
Life of this patent
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Abstract
The present invention relates to a gas-generating micelle for reducing localized fat. In the present invention, by forming a micelle using a material having high biocompatibility and also introducing a cell-targeting ligand (peptide) onto the surface of the micelle, delivery to surrounding cells and tissues other than adipocytes can be minimized, and delivery into adipocytes can be maximized. The gas-generating micelle for reducing localized fat according to the present invention can be produced as an injectable preparation, and can be applied to local lipolysis supplements or diet beauty products that break down localized fat.
Claims8
A gas-generating micelle for reducing fat, comprising a compound represented by the following Chemical Formula 3,
- wherein the micelle is 150 to 500 nm in a diameter, and
- wherein adipocyte is destroyed by carbon dioxide generated by hydrolysis of the compound:
- wherein in the Chemical Formula 3, p is an integer of 12 to 227, and q is an integer of 2 to 14.
A method for preparing a gas-generating micelle for reducing fat comprising a compound represented by the following Chemical Formula 3, wherein the micelle is 150 to 500 nm in a diameter, and the method comprises the steps of:
- synthesizing a polyethylene glycol derivative that is a compound represented by Chemical Formula 4 by mixing polyethylene glycol and alkyl chloroformate;
- synthesizing a peptide-bound polyethylene glycol derivative by binding one or more peptides selected from the group consisting of an adipocyte-targeting sequence peptide and an arginine 9 peptide to the polyethylene glycol derivative;
- and
- synthesizing a micelle by evaporating a solvent after dissolving the polyethylene glycol derivative and the peptide-bound polyethylene glycol derivative in one or two or more mixture solvents selected from acetonitrile, methylene chloride, chloroform and methanol:
- wherein in the Chemical Formula 3 or 4, R1 is a hydrogen, a C1 to C5 alkyl group, an amine group, a C1 to C5 alkylamine group, a carboxyl group, or a C1 to C5 alkylcarboxyl group, p is an integer of 12 to 227, and q is an integer of 2 to 14.
Dependencies are inferred from the claim text.