Systems and methods for surgical navigation

A method for use with an imaging system having an imaging modality from at least one of an X-ray, a computerized tomography (CT), a magnetic resonance imaging (MRI), an ultrasound, a positron emission tomography (PET), a single-photon emission computed tomography (SPECT), an optical coherence tomography (OCT), a fluorescence imaging, a fluoroscopic imaging, and an infrared imaging, the method comprising:

• adjusting a view of a three-dimensional image of a subject to a desired view of the three-dimensional image;
• obtaining a two-dimensional image reconstruction from the three-dimensional image of the subject at the desired view;
• identifying a physical position for a physical imaging device that is associated with the desired view;
• and
• registering position addresses of the three-dimensional image with positions of the physical imaging device,
• wherein registering position addresses of the three-dimensional image with positions of the physical imaging device comprises:
• obtaining a first image of the subject from the physical imaging device at a first location of the physical imaging device;
• obtaining a second image of the subject from the physical imaging device at a second location of the physical imaging device;
• comparing the first image of the subject and the second image of the subject to the two-dimensional image reconstruction from the three-dimensional image of the subject;
• and
• associating the position addresses of the three-dimensional image with the positions of the physical imaging device based on the first location, the second location, and the comparison of the first image of the subject and the second image of the subject to the two-dimensional image reconstruction from the three-dimensional image of the subject.