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US 12,453,512 B2Granted
Tumor ablation planning using interstitial optical mapping
AssigneeMedtronic Navigation, Inc.
InventorMatthew W. Koenig
Life of this patent
Estimating the term…
Abstract
Devices, systems, and methods to generate a plan for an interstitial laser ablation procedure are disclosed. The systems may be configured as an interstitial optical mapping system including a catheter, an emitter optical fiber, an imaging optical fiber, a light source, and a processing unit. The emitter optical fiber and the imaging optical fiber are used to interstitially image a fluorescent dye associated with a tumor, including the tumor margin, at discrete imaging positions along a length of the catheter. The processor calculates a location of the fluorescent dye at each discrete position and creates an optical map representing the tumor. The optical map is used to generate an interstitial laser ablation plan that includes laser fiber pull-back positions.
Claims19
An optical tumor mapping system, comprising:
- an emitter optical fiber configured to emit light;
- an imaging optical fiber configured to receive light, wherein the emitter optical fiber and the imaging optical fiber are configured to be selectively slidingly disposed within a catheter;
- and
- a processor configured to:
- generate, via the light received by the imaging optical fiber as the emitter optical fiber and the imaging optical fiber are moved along the catheter, a computerized representation of a margin of a target tissue structure,
- wherein the light received by the imaging optical fiber is received while the emitter optical fiber and the imaging optical fiber are at a first position within the catheter and at a second position within the catheter, while the catheter penetrates entirely through the target tissue structure,
- wherein the first position is at a distal end of the catheter that has penetrated entirely through the target tissue structure such that, in the first position, the imaging optical fiber and the emitter optical fiber are in a region of the catheter that is outside the target tissue structure,
- wherein the second position is further away from the distal end of the catheter than the first position such that, in the second position, the imaging optical fiber and the emitter optical fiber are in a region of the catheter that is within the target tissue structure, and
- wherein the processor is configured to perform a spectral analysis on the light received by the imaging optical fiber at the first position and the second position to generate the computerized representation of the margin of the target tissue structure, and to identify non-cancerous tissue;
- and
- generate a laser ablation plan to guide a laser ablation procedure based on the computerized representation of the margin of the target tissue structure and the identified non-cancerous tissue.
8 more elements
A method of planning a tumor ablation procedure, comprising:
- causing a catheter to penetrate through a target tissue structure;
- exciting a fluorescent dye with light emitted from an emitter optical fiber from within the catheter while disposed within the target tissue structure;
- receiving reflected light from the excited fluorescent dye with an imaging optical fiber,
- wherein receiving the reflected light with the imaging optical fiber occurs while the emitter optical fiber and the imaging optical fiber are at a first position within the catheter and at a second position within the catheter, while the catheter penetrates entirely through the target tissue structure,
- wherein the first position is at a distal end of the catheter that has penetrated entirely through the target tissue structure such that, in the first position, the imaging optical fiber and the emitter optical fiber are in a region of the catheter that is outside the target tissue structure,
- wherein the second position is further away from the distal end of the catheter than the first position such that, in the second position, the imaging optical fiber and the emitter optical fiber are in a region of the catheter that is within the target tissue structure;
- and
- performing a spectral analysis on the reflected light received by the imaging optical fiber at the first position and the second position to generate a computerized representation of a margin of the target tissue structure, and to identify non-cancerous tissue;
- and
- generating a laser ablation plan to guide a laser ablation procedure based on the computerized representation of the margin of the target tissue structure and the identified non-cancerous tissue.
7 more elements
A system for confirming ablation of a tumor, comprising:
- an emitter optical fiber configured to emit light;
- an imaging optical fiber configured to receive light, wherein the emitter optical fiber and the imaging optical fiber are configured to be selectively slidingly disposed within a catheter;
- and
- a processor configured to:
- generate, via the light received by the imaging optical fiber as the emitter optical fiber and the imaging optical fiber are moved along the catheter, a computerized representation of a margin of a tumor,
- wherein the light received by the imaging optical fiber is received while the emitter optical fiber and the imaging optical fiber are at a first position within the catheter and at a second position within the catheter, while the catheter penetrates entirely through tumor,
- wherein the first position is at a distal end of the catheter that has penetrated entirely through the tumor such that, in the first position, the imaging optical fiber and the emitter optical fiber are in a region of the catheter that is outside the tumor,
- wherein the second position is further away from the distal end of the catheter than the first position such that, in the second position, the imaging optical fiber and the emitter optical fiber are in a region of the catheter that is within the tumor, and
- wherein the processor is configured to perform a spectral analysis on the light received by the imaging optical fiber at the first position and the second position to generate the computerized representation of the margin of the tumor, and to identify non-cancerous tissue;
- generate a first laser ablation plan to guide a first laser ablation procedure based on the computerized representation of the margin of the tumor and the identified non-cancerous tissue;
- cause the emitter optical fiber to emit light from within an ablated portion of the tumor to excite a fluorescent dye associated with non-ablated portions of the tumor, wherein the ablated portion of the tumor was ablated according to the first laser ablation plan;
- and
- process data associated with reflected light received by the imaging optical fiber to detect a presence of the non-ablated portions;
- wherein when the presence of the non-ablated portions is not detected, the processor is configured to confirm the first laser ablation procedure was successful;
- and
- wherein when the presence of the non-ablated portions is detected the processor is configured to:
- map a position of the non-ablated portions along a length of the catheter;
- and
- generate a supplemental laser ablation plan for an additional ablation procedure.
16 more elements
Dependencies are inferred from the claim text.