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US 12,453,484 B2Granted
Maternal and fetal heart rate monitor
AssigneeThe Regents of the University of California
InventorsDennis Matthews, Xiaomeng Gao, Xiaonan Jiang, Xiaoguang Liu, Jeremy Thompson, Kylie Dunning, Kenneth Pawlak, Chris Ryman
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Abstract
Described herein are systems, devices, and methods for non-invasive pregnancy testing. The systems, devices, and methods can be used to provide pregnancy status information of a subject by detecting cardiovascular activity of a fetus in the subject. Subjects can include ruminants, ungulates, and humans.
Claims18
A handheld pregnancy detection device comprising:
- an antenna configured for placement adjacent to hair, dermis, or combination of hair and dermis of a non-human mammalian potentially pregnant subject;
- a continuous wave (CW) Doppler radar transmitter electrically coupled to the antenna and configured to transmit electromagnetic (EM) signals via the antenna with sufficient power to penetrate between about 5 cm and about 50 cm of the dermis, muscle, bone, and body tissue of the subject to reach a heart of a fetus in the subject;
- a radar receiver electrically coupled to the antenna and configured to receive EM signals, via the antenna, reflected from the fetus and that repenetrate between the about 5 cm and the about 50 cm of the dermis, muscle, bone, and body tissue of the subject, wherein mechanical contraction and expansion of the heart of the fetus creates a doppler shift that is modulated into reflected EM signals, wherein the received reflected EM signals have a signal to noise ratio sufficiently high to tolerate user induced hand motions of the handheld device and minute motions of the fetus, the reflected EM signals comprising raw in-phase and quadrature (I/Q) data that includes periodic frequency of motion data;
- and
- a processor configured to:
- segment the raw in-phase and quadrature (I/Q) data into data segments;
- linearly detrend the data segments to identify I/Q data segments of interest;
- process the data segments of interest to remove low-frequency drifting high frequency noise, and/or abrupt signal changes, and generate clean data segments;
- demodulate the clean data segments to extract motion information and produce an extracted mixture motion profile that contains maternal heart rate (MHR), maternal respiration rate (MRR), and fetal heart rate (FHR) data;
- bandpass filter and Fast Fourier transform the mixed motion profile to separate MHR and MRR data from FHR data;
- and
- extract the FHR data, including the periodic frequency of motion data, as an indicator of fetal heart motion of the fetus.
9 more elements
A method implementing a handheld pregnancy detection system comprising an antenna, a continuous wave (CW) Doppler radar transmitter electrically coupled to the antenna, and a radar receiver electrically coupled to the antenna, the method comprising:
- in response to placing the antenna adjacent to hair, dermis, or combination of hair and dermis of a non-human mammalian potentially pregnant subject:
- transmitting, using the transmitter and the antenna, electromagnetic (EM) signals through tissue of the subject with sufficient power to penetrate between about 5 cm and about 50 cm of the dermis, muscle, bone, and body tissue of the subject to reach a heart of a fetus in the subject;
- receiving, using the receiver and the antenna, EM signals reflected from the fetus in response to the transmitted electromagnetic waves EM signals and that repenetrate between the about 5 cm and the about 50 cm of the dermis, muscle, bone, and body tissue of the subject, wherein mechanical contraction and expansion of the heart of the fetus creates a doppler shift that is modulated into reflected EM signals, wherein the received reflected EM signals have a signal to noise ratio sufficiently high to tolerate user induced hand motions of the handheld system and minute motions of the fetus, the reflected EM signals comprising raw in-phase and quadrature (I/Q) data that includes periodic frequency of motion data;
- segmenting the raw in-phase and quadrature (I/Q) data into data segments;
- linearly detrending the data segments to identify I/Q data segments of interest;
- processing the data segments of interest to remove low-frequency drifting, high frequency noise, and/or abrupt signal changes, and generate clean data segments;
- demodulating the clean data segments to extract motion information and produce an extracted mixture motion profile that contains maternal heart rate (MHR), maternal respiration rate (MRR), and fetal heart rate (FHR) data;
- bandpass filtering the mixed motion profile and transforming the mixed motion profile with a Fast Fourier transform to separate MHR and MRR data from FHR data;
- and
- extracting the FHR data, including the periodic frequency of motion data, as an indicator of fetal heart motion of the fetus.
7 more elements
Dependencies are inferred from the claim text.