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US 12,448,624 B2Granted
Modified nucleic acid having improved treatment efficacy, and anticancer pharmaceutical composition containing same
AssigneeInteroligo Corporation
InventorsJung Hwan Lee, Jong Ook Lee
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Abstract
An oligonucleotide variant according to an embodiment of the present disclosure has a structure of Formula 1 may exhibit excellent in-vivo stability and anticancer effects: (N)x-[TGG]m[TTG][TGG]n-(M)y [Formula 1] wherein, N and M are independently deoxyuridine (dU), deoxycytidine (dC), uridine (U), or cytidine (C), in which a halogen or hydroxy group is bound to 5- or 2′-position thereof; x and y are independently integers of 0 to 10 (except when x and y are simultaneously 0), n is an integer of 1 to 10; and m is an integer of 1 to 10.
Claims11
An oligonucleotide variant having a structure of Formula 1 below:
- [Formula 1]
- (N)x-[TGG]m[TTG][TGG]n-(M)y
- wherein, N and M are independently deoxyuridine (dU), deoxycytidine (dC), uridine (U), or cytidine (C), in which a halogen or hydroxy group is bound to 5- or 2′-position thereof;
- x and y are independently integers of 0 to 10 with a proviso that x and y are not simultaneously 0, n is an integer of 4 to 6;
- and m is an integer of 4 to 6.
2 more elements
Dependencies are inferred from the claim text.