Substrate for testing samples and system comprising the same
Assigneeibidi GmbH
InventorRoman Zantl
Life of this patent
Estimating the term…
Abstract
The invention relates to a substrate for testing samples, in particular cells or molecules, wherein the substrate comprises a fluid system comprising a sample chamber configured in the substrate for storing and testing samples and at least one liquid reservoir in fluid communication with the sample chamber, and wherein the substrate comprises a passive blocking element capable of assuming a closed position and an open position, wherein in the closed position a fluid exchange between the sample chamber and the liquid reservoir is blocked.
Claims18
A substrate for testing samples, in particular cells or molecules, wherein the substrate comprises;
- a fluid system comprising:
- a sample chamber configured in the substrate for storing and testing samples;
- a first liquid reservoir and a second liquid reservoir each in fluid communication with the sample chamber;
- a first passive blocking element and a second passive blocking element that can each assume a closed position and an open position, wherein in the closed position a fluid exchange between the sample chamber and at least one of the first liquid reservoir or the second liquid reservoir is blocked;
- and
- at least two first fluid channels and at least two second fluid channels which are directly in fluid communication with the sample chamber;
- wherein one of the first fluid channels is part of the first liquid reservoir or is directly in fluid communication therewith and is directly adjacent to one of the second fluid channels, and the first passive blocking element is arranged therebetween;
- wherein another of said first fluid channels is part of or directly in fluid communication with said second liquid reservoir and is directly adjacent to another of said second fluid channels, and said second passive blocking element is arranged therebetween.
A substrate for testing samples, in particular cells or molecules, wherein the substrate comprises:
- a fluid system comprising:
- a sample chamber configured in the substrate for storing and testing samples;
- at least one liquid reservoir in fluid communication with the sample chamber;
- a first fluid channel that is part of or directly in fluid communication with the liquid reservoir;
- a second fluid channel that is directly in fluid communication with the sample chamber, wherein the first fluid channel is directly adjacent to the second fluid channel;
- and
- at least one passive blocking element arranged between the first fluid channel and the second fluid channel that can assume a closed position and an open position, wherein in the closed position a fluid exchange between the sample chamber and the at least one liquid reservoir is blocked;
- wherein the first fluid channel and the second fluid channel, in a region in which the first fluid channel is directly adjacent to the second fluid channel, are arranged overlapping each other in a top view of the substrate, and the first fluid channel is arranged above or below the second fluid channel.
A substrate for testing samples, in particular cells or molecules, wherein the substrate comprises:
- a fluid system comprising a sample chamber configured in the substrate for storing and testing samples and a liquid reservoir in fluid communication with the sample chamber;
- at least one passive blocking element that can assume a closed position and an open position, wherein in the closed position a fluid exchange between the sample chamber and the liquid reservoir is blocked;
- and
- at least one connection, wherein the substrate is configured such that gas can enter, in particular be pumped, into the liquid reservoir via the at least one connection.
A substrate for testing samples, in particular cells or molecules, wherein the substrate comprises:
- a fluid system comprising a sample chamber configured in the substrate for storing and testing samples and at least one liquid reservoir in fluid communication with the sample chamber;
- at least one passive blocking element that can assume a closed position and an open position, wherein in the closed position a fluid exchange between the sample chamber and the at least one liquid reservoir is blocked;
- and
- a displacement member comprising a chamber having no fluidic communication with the liquid reservoir and at least one connection;
- wherein the displacement member is configured in such a way that pumping gas and/or liquid into the chamber increases a volume of the chamber;
- and
- wherein the substrate is formed and arranged in such a way that gas and/or liquid can be pumped into the chamber via the connection and that a volume of the liquid reservoir is reduced when a volume of the chamber is increased by pumping gas and/or liquid into the chamber.
Dependencies are inferred from the claim text.