Drug delivery compositions and applications thereof
AssigneeThe University of North Carolina at Chapel Hill
InventorsAlexander Kabanov, Duhyeong Hwang, Marina Sokolsky
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Abstract
In one aspect, amphiphilic block copolymers are described herein comprising a first block and a second block, the second block including monomer having a side chain comprising a heteroaryl moiety, wherein the second block is more hydrophobic than the first block. In some embodiments, the heteroaryl moiety is a five-membered ring or six membered ring. Amphiphilic block copolymers described herein, in some embodiments, can be used to form micellar compositions for solubilizing and delivering water insoluble pharmaceutical and/or therapeutic agents.
Claims20
An amphiphilic block copolymer comprising:
- a first block and a second block, the second block including oxazoline monomer having a side chain comprising a heteroaryl moiety, wherein the second block is more hydrophobic than the first block, and the heteroaryl moiety is of the formula:
- wherein X, Y and Z are heteroatoms independently selected from the group consisting of N, O, and S, and R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, aryl, heteroaryl, amine, —SH, hydroxyl, halo, carboxyl, and —CONR3 wherein R3 is alkyl and represents a point of attachment of the heteroaryl moiety to the monomer.
An amphiphilic block copolymer comprising:
- a first block and a second block, the second block including monomer having a side chain comprising a heteroaryl moiety, wherein the second block is more hydrophobic than the first block comprises poly (2-N,N-dimethyl-1,3,5-triazine-2,4-diamine-6-ethyl-2-oxazoline).
Dependencies are inferred from the claim text.