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US 12,448,461 B2Granted
ABCB5 ligands and substrates
AssigneeChildren's Medical Center Corporation
InventorMarkus H. Frank
Life of this patent
Estimating the term…
Abstract
The present invention is directed to methods and compositions for modulating ABCB5+ stem cell activity. The invention also relates to assays and reagents for manipulating and characterizing compounds that modulate ABCB5+ cell signaling.
Claims3
A composition comprising a synthetic phospholipid, comprising a compound having the structure:
- wherein the phospholipid comprises two fatty acids, wherein each of the fatty acids comprises a carboxyl linked to a carbon atom chain identified by R1 and R2 and wherein R1 and R2 independent of one another have a length defined by a number of carbon atoms acid chains;
- and
- wherein one of R1 and R2 has a length that is at least twice as long as the other of R1 and R2, and wherein the phospholipid has a formula:
- C33H65Q19P3.
1 more element
A composition comprising a synthetic phospholipid, comprising a compound having the structure:
- wherein the phospholipid comprises two fatty acids, wherein each of the fatty acids comprises a carboxyl linked to a carbon atom chain identified by R1 and R2 and wherein R1 and R2 independent of one another have a length defined by a number of carbon atoms acid chains;
- wherein one of R1 and R2 has a length that is at least twice as long as the other of R1 and R2, and wherein the composition enhances ABCB5-PIP2 pathway.
Dependencies are inferred from the claim text.