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US 12,448,425 B2Granted
Therapeutic peptides
AssigneeBoard of Regents, The University of Texas System
InventorsChun Li, Chiyi Xiong, Yunfei Wen, Anil Sood
Life of this patent
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Abstract
Provided herein are therapeutic peptides. In some aspects, therapeutic peptides are provided that can alter EphB4/EFNB2 signaling and can be used to treat a cancer. In some embodiments, the peptides are comprised in nanoparticles, such as core-cross-linked polymeric micelles (CCPM).
Claims38
A non-natural peptide comprising TNd (Y) LFSPNGPIARAW (SEQ ID NO:1) or a sequence that has 1, 2, 3, or 4 amino acid substitutions relative to SEQ ID NO:
- 1 and retains the D-amino acid at position 3 of SEQ ID NO:1.
Dependencies are inferred from the claim text.