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US 12,448,420 B2Granted
Pharmaceutical composition, comprising recombinant stabilized galectin 9 protein, for prevention or treatment of rheumatoid arthritis and bone disease
AssigneeGbiologics Inc.
InventorDong Ho Song
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Abstract
The present invention relates to a recombinant stabilized galectin 9 protein and the use thereof, and more specifically, relates to a pharmaceutical composition comprising the recombinant stabilized galectin 9 protein for prevention or treatment of rheumatoid arthritis and a bone disease. The recombinant stabilized galectin 9 protein differs from the wild-type galectin 9 protein in that the amino acids in the link region connecting two carbohydrates recognition domains (CRDs) are deleted, and the amino acids in the C-terminal CRD (CCRD) are deleted and substituted.
Claims4
A method for treatment of a bone disease, comprising:
- administering to an individual in need thereof a pharmaceutically effective amount of a recombinant stabilized galectin 9 protein having the amino acid sequence set forth as SEQ ID NO:
- 1,
- wherein the bone disease is rheumatoid arthritis.
Dependencies are inferred from the claim text.