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US 12,448,413 B2Granted
HSP70-derived peptide, pharmaceutical composition for treating or preventing cancer using same, immunity inducer, and method for producing antigen presenting cell
AssigneeNEC Corporation
InventorsTomoya Miyakawa, Masaaki Oka, Shoichi Hazama, Koji Tamada, Keiko Udaka
Life of this patent
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Abstract
The present invention provides a peptide containing 8 or more consecutive amino acid residues in an amino acid sequence of any of SEQ ID NOS: 1 to 15 and consisting of 11 or less amino acid residues.
Claims6
A pharmaceutical composition for inducing an immune response in a subject suffering from cancer, comprising a peptide consisting of a variant of the amino acid sequence of SEQ ID NO:
- 7,
- wherein the variant consists of nine amino acid residues, and wherein in the amino acid sequence of the variant, the amino acid corresponding to position 2 of the amino acid sequence of SEQ ID NO:
- 7 is substituted by tyrosine, phenylalanine, methionine, tryptophan, valine, leucine, or glutamine;
- and/or the amino acid at the C-terminal is substituted by phenylalanine, leucine, tryptophan, methionine, or valine.
1 more element
A pharmaceutical composition for inducing an immune response to treat cancer, comprising a peptide consisting of a variant of the amino acid sequence of SEQ ID NO:
- 7,
- wherein the variant consists of nine amino acid residues, and wherein in the amino acid sequence of the variant, the amino acid corresponding to position 2 of the amino acid sequence of SEQ ID NO:
- 7 is substituted by tyrosine, phenylalanine, methionine, tryptophan, valine, leucine, or glutamine;
- and/or the amino acid at the C-terminal is substituted by phenylalanine, leucine, tryptophan, methionine, or valine.
1 more element
Dependencies are inferred from the claim text.