1,3-cyclohexanedione derivatives and 1,3-cyclopentanedione derivatives as buffering molecules in non-aqueous solutions
AssigneeOkinawa Institute of Science and Technology School Corporation
InventorsFujie Tanaka, Muhammad Sohail
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Abstract
This invention relates to 1,3-cyclohexanedione derivatives and 1,3-cyclopentanedione derivatives that have buffering function in non-aqueous solutions and to the use thereof for tuning the conditions to control chemical events in non-aqueous solutions. One aspect of the invention is a method for buffering a non-aqueous solution, including adding a buffering molecule to the non-aqueous solution, in which the non-aqueous solution contains an organic solvent, the buffering molecule is a 1,3-cyclohexanedione derivative or a 1,3-cyclopentanedione derivative, and the buffering molecule is optionally conjugated to a solid support.
Claims10
In a method of buffering a non-aqueous solution comprising an organic solvent comprising adding a buffering molecule, the improvement wherein said buffering molecule is a compound presented by Formula I:
- wherein R1 to R5 each are hydrogen oralkyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, or acyl, which is optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxy, acyl, carboxyl, carboxyamide, carboxylic acid ester, haloalkyl, halo-alkoxy, aryl, heterocycloalkyl, and heteroaryl, or Formula II:
- wherein R1 to R3 each are hydrogen or alkyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, or acyl, which is optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxy, acyl, carboxyl, carboxyamide, carboxylic acid ester, haloalkyl, halo-alkoxy, aryl, heterocycloalkyl, and heteroaryl.
A method for controlling structural change of a compound in a non-aqueous solution, wherein an acid or a base is capable of causing structural change of the compound, and
- the method comprises preparing a non-aqueous solution comprising the compound and a buffering molecule represented by Formula I:
- wherein R1 to R5 each are hydrogen alkyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, or acyl, which is optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxy, acyl, carboxyl, carboxyamide, carboxylic acid ester, haloalkyl, halo-alkoxy, aryl, heterocycloalkyl, and heteroaryl, or Formula II:
- wherein R1 to R3 each are hydrogen or alkyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, or acyl, which is optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxy, acyl, carboxyl, carboxyamide, carboxylic acid ester, haloalkyl, halo-alkoxy, aryl, heterocycloalkyl, and heteroaryl.
A non-aqueous solution comprising:
- a compound in which an acid or a base is capable of causing structural change of the compound, and
- a buffering molecule represented by Formula I:
- wherein R1 to R5 each are hydrogen or alkyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, or acyl, which is optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxy, acyl, carboxyl, carboxyamide, carboxylic acid ester, haloalkyl, halo-alkoxy, aryl, heterocycloalkyl, and heteroaryl, or Formula II:
- wherein R1 to R3 each are hydrogen or alkyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, or acyl, which is optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxy, acyl, carboxyl, carboxyamide, carboxylic acid ester, haloalkyl, halo-alkoxy, aryl, heterocycloalkyl, and heteroaryl.
An article comprising:
- a solid support, wherein the solid support is a resin;
- and
- a buffering molecule conjugated to the solid support and represented by Formula I:
- wherein R1 to R5 each are hydrogen or alkyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, or acyl, which is optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxy, acyl, carboxyl, carboxyamide, carboxylic acid ester, haloalkyl, halo-alkoxy, aryl, heterocycloalkyl, and heteroaryl, and one of R1 to R5 is conjugated to the solid support, or Formula II:
- wherein R1 to R3 each are hydrogen or alkyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, or acyl, which is optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxy, acyl, carboxyl, carboxyamide, carboxylic acid ester, haloalkyl, halo-alkoxy,
- aryl, heterocycloalkyl, and heteroaryl, and one of R1 to R3 is conjugated to the solid support.
Dependencies are inferred from the claim text.