Method of filling degassed drug product into containers and drug product filling device

A method of filling at least one liquid drug product into containers, comprising:

• A) providing at least one drug product filling device configured for filling at least one liquid drug product into containers, wherein step A) further comprises:
• i) providing a drug product preparer configured for preparing the liquid drug product;
• ii) providing a filling station configured for filling the liquid drug product into the containers, the filling station being fluidically coupled to the drug product preparer;
• iii) providing a degasser fluidly interposed between the drug product preparer and the filling station and the degasser comprising at least one degasser membrane for separating off at least one gas from the liquid drug product, wherein the degasser comprises at least one hollow fiber membrane module including a plurality of hollow fibers at least partially formed by the degasser membrane, the plurality of hollow fibers having a first side and an opposing second side, the first side defining an interior lumen receiving the liquid drug product, wherein the hollow fibers are at least partially formed by the degasser membrane and are sterilizable, wherein the hollow fibers form fiber bundles having opposing ends embedded in opposed sealings;
• iv) providing at least one in-line filtering device fluidically interposed between the drug product preparer and the filling station, wherein the in-line filtering device comprises a sterile filter;
• B) conducting the liquid drug product from the drug product preparer to the filling station, wherein the liquid drug product is at least partially degassed upon passing through the degasser;
• and
• C) filling the at least partially degassed liquid drug product into the containers using the filling station.

A method of increasing the accuracy of the filling weight of a liquid drug product in a container, the method comprising:

• I. preparing the liquid drug product via a drug product preparer;
• II. degassing the liquid drug product by at least partially separating off at least one gas from the liquid drug product by using a degasser, the degasser comprising at least one degasser membrane, wherein the degasser comprises at least one hollow fiber membrane module including a plurality of hollow fibers at least partially formed by the degasser membrane, the plurality of hollow fibers having a first side and an opposing second side, the first side defining an interior lumen receiving the liquid drug product, wherein the hollow fibers are at least partially formed by the degasser membrane and are sterilizable, wherein the hollow fibers form fiber bundles having opposing ends embedded in opposed sealings;
• III. providing at least one in-line filtering device fluidically interposed between the drug product preparer and a filling station, wherein the in-line filtering device comprises a sterile filter;
• IV. filling the degassed liquid drug product into the container via the filling station.