Systems and methods for determining neuromodulation parameters

A non-transitory machine-readable medium including instructions, which when executed by a machine, cause the machine to perform operations, comprising:

• stimulating an external location on a patient's body to evoke a first instance of nerve activity;
• sensing a first evoked compound action potential (ECAP) signal indicative of the first instance of nerve activity at a location within the patient's body;
• determining first data corresponding to the first instance of nerve activity, wherein the first data includes a first instance of at least one ECAP feature from the first ECAP signal, wherein the at least one ECAP feature includes for a waveform portion one or more of:
• an amplitude of the waveform portion, a delay of the waveform portion, a width of the waveform portion, a length of a curve for the waveform portion, an area under the curve for the waveform portion, or a ratio of amplitudes within the waveform portion;
• stimulating an internal location within the patient's body using at least one stimulation parameter, wherein stimulation of the internal location evokes a second instance of nerve activity;
• sensing a second ECAP signal indicative of the second instance of nerve activity at the location within the patient's body;
• determining second data corresponding to the second instance of nerve activity, wherein the second data includes a second instance of the at least one ECAP feature from the second ECAP signal;
• evaluating a relationship between the first data and the second data, including evaluating a signal-to-signal relationship between the first instance of the at least one ECAP feature from the first ECAP signal and the second instance of the at least one ECAP feature from the second ECAP signal;
• adjusting the at least one stimulation parameter based on the relationship between the first data and the second data, including based on the signal-to-signal relationship between the first instance of the at least one ECAP feature and the second instance of the at least one ECAP feature;
• and
• stimulating the internal location using the adjusted at least one stimulation parameter.

A system, comprising:

• external stimulation circuitry configured for stimulating an external location on a patient's body to evoke a first instance of nerve activity within the patient's body;
• internal stimulation circuitry configured for stimulating an internal location within the patient's body using at least one stimulation parameter, wherein stimulation of the internal location evokes a second instance of nerve activity within the patient's body;
• sensing circuitry configured for sensing a first evoked compound action potential (ECAP) signal indicative of the first instance of nerve activity at a sensing location within the patient's body and a second electrical signal indicative of the second instance of nerve activity at the sensing location within the patient's body;
• and
• control circuitry configured for determining first data corresponding to the first instance of nerve activity, wherein the first data includes a first instance of at least one ECAP feature from the first ECAP signal and determining second data corresponding to the second instance of nerve activity, wherein the second data includes a second instance of the at least one ECAP feature from the second ECAP signal, evaluating a relationship between the first data and the second data, including evaluating a signal-to-signal relationship between the first instance of the at least one ECAP feature from the first ECAP signal and the second instance of the at least one ECAP feature from the second ECAP signal, adjusting the at least one stimulation parameter based on the relationship between the first data and the second data, including based on the signal-to-signal relationship between the first instance of the at least one ECAP feature and the second instance of the at least one ECAP feature, and controlling the internal stimulation circuitry to stimulate the internal location using the adjusted at least one stimulation parameter.