Dry powder inhaler and system for drug delivery

A dry powder inhaler comprising:

• a sled or slide tray,
• a mouthpiece, and
• a cartridge including a container, a lid, and at least one opening configured as an inlet and at least one opening configured as an outlet,
• wherein the container and the lid are both rigid parts,
• wherein movement of the mouthpiece actuates movement of the container relative to the lid from a powder containment position to a dosing position,
• wherein the dry powder inhaler is configured to attain an open or container loading position, and a closed or dosing position,
• wherein the mouthpiece actuates the sled or slide tray during movement between the open position and the closed position or from the closed position to the open position,
• wherein the container includes a dry powder including a vasoactive agent, and
• wherein the dry powder has a rugosity of about 11 to about 16.