Method and device for in vivo tissue regeneration on the interior surface of hollow organs

A method of treating a localized trauma located on a region defined on an inner surface of an intact non-resected hollow organ, the method comprising:

• applying a synthetic cellular delivery device having edge regions, wherein the synthetic cellular delivery device is in overlying relationship with the localized trauma located on the region defined on the inner surface of the intact non-resected hollow organ, the synthetic cellular delivery device having an organ-contacting surface and at least one colonized cell line adhering to the organ-contacting surface, wherein the localized trauma located on the region defined on the inner surface of the intact non-resected hollow organ is caused by at least one of disease, injury caused by one of penetrating injury, blunt injury, iatrogenic injury, laceration, or medical treatment caused by biopsy, debriding, wherein the localized trauma has a surface area and wherein the synthetic cellular delivery device is applied such that edge regions of the synthetic cellular delivery device extend beyond the localized trauma located on the region defined on the inner surface of the intact non-resected hollow organ and contact native tissue;
• after application, allowing the synthetic cellular delivery device to remain in contact with the localized trauma located on the region defined on the inner surface of the intact non-resected hollow organ for an interval sufficient to permit the at least one colonized cell line to signal and interact with intact hollow organ tissue proximate to the localized trauma to achieve guided tissue growth in tissue of the intact non-resected hollow organ proximate to the localized trauma;
• and
• removing the synthetic cellular delivery device from contact with the inner surface of the intact non-resected hollow organ after the guided tissue growth has occurred and the interval has expired,
• wherein the synthetic cellular delivery device comprises:
• a body section, the body section having a first end and a second end opposed to the first end, a first face defined between the first end and the opposed second end, the first face configured to overlay a portion of the inner surface of the hollow organ and defining the organ contacting face and an opposed second face, wherein the first face of the body section has at least one region composed of spun polymeric fibers, the spun polymeric fibers having an average fiber diameter between 15 nm and 10 microns, at least a portion of the spun polymeric fibers interlinked to form pores having an average pore opening less than 50 microns and define a porous region and wherein the first face of the body section of the synthetic cellular delivery device defines an arcuate surface, wherein an arc defined has a value between 15° and 350°;
• and
• at least one colonized cell line adhering to the porous region defined on the first face of the of the body section,
• wherein the synthetic cellular delivery device is interior to and overlays the localized trauma located on the region defined on the inner surface of the intact non-resected hollow organ and wherein external regions of the intact non-resected hollow organ are located exterior to the localized trauma when the synthetic cellular delivery device is in position.