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US 12,447,229 B2Granted
Bone implant
AssigneeBonAlive Oy
InventorsFredrik Ollila, Nina Lindfors, Robert Bjorkenheim, Gustav Stromberg, Leena Hupa, Peter Uppstu, Jukka Pajarinen
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Abstract
The present invention relates to a bone implant comprising a porous body comprising particles of bioactive glass having a particle size of at least 500 μm, wherein the composition of the bioactive glass is 45-59 weight-% of SiO2, 18-25 weight-% of Na2O, 17-25 weight-% of CaO and 0.1-6 weight-% of P2O5, and a film having a thickness of 10 μm-200 μm, made of a biocompatible polymer and arranged at least partially around the body.
Claims14
A bone implant comprising
- a porous body comprising particles of bioactive glass comprising a particle size of at least 500 μm, wherein a composition of the particles of bioactive glass comprises 45-59 weight-% of SiO2, 18-25 weight-% of Na2O, 17-25 weight-% of CaO and 0.1-6 weight-% of P2O5, wherein the porous body has an outer surface, and
- an external film comprising a thickness of 10 μm-200 μm, made of a biocompatible polymer;
- wherein the external film is provided only on a portion of the outer surface and is arranged on the outer surface so as to contact muscle, fascia or periosteum when the bone implant is implanted in a bone;
- wherein the biocompatible polymer is selected from a group consisting of polylactide, polyglycolide, poly(lactide-co-glycolide), polycaprolactone, natural collagen polymers and their mixtures with polyethylene glycol;
- and
- wherein the implant induces VEGF expression at at least 8 weeks post implantation.
3 more elements
A bone implant comprising
- a porous body comprising particles of bioactive glass comprising a particle size of at least 500 μm, wherein a composition of the particles of bioactive glass comprises 45-59 weight-% of SiO2, 18-25 weight-% of Na2O, 17-25 weight-% of CaO and 0.1-6 weight-% of P2O5, and
- an external film comprised of PLGA and comprising a thickness of 17-192 μm, wherein the implant induces VEGF expression at at least 8 weeks post implantation.
Dependencies are inferred from the claim text.