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US 12,447,215 B2Granted
Nanoparticle probes and methods of making and use thereof
OwnerPaul C. Leeinventor
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Abstract
Some embodiments relate to nanoparticle probes for the detection of disease states in a patient or for tissue engineering. In some embodiments, the nanoparticle probe comprises one or more slip bonds that bind to a cell surface structure. In some embodiments, the binding of the nanoparticle probe is selective. In some embodiments, the nanoparticle probe binds to cells having a certain maximum glycocalyx thickness.
Claims24
A nanoparticle probe comprising:
- a nanoparticle base structure functionalized with a therapeutic agent, wherein the therapeutic agent is a growth factor;
- and
- a slip bond moiety comprising a ligand for a glycocalyx of a cell;
- a polymeric tether functionalized to the nanoparticle base structure and to an associative moiety, wherein said associative moiety comprises a ligand for a cell surface protein, a receptor, or a biomarker;
- and
- wherein the associative moiety preferentially binds to the protein, the receptor, and the biomarker of the cell based on the thickness of a glycocalyx layer of the cell.
3 more elements
Dependencies are inferred from the claim text.