Nanoparticle vaccines with novel structural components
AssigneeThe Scripps Research Institute
InventorsLinling He, Jiang Zhu
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Abstract
The present invention provides novel nanoparticle presented vaccine compositions that are stabilized with a locking domain. Various immunogens can be employed in the preparation of the vaccine compositions, including viral immunogens such as HIV-1 and Ebola viral immunogens, and non-viral immunogens such as immunogens derived from bacteria, parasites and mammalian species. The invention also provides methods of using such vaccine compositions in various therapeutic applications, e.g., for preventing or treating viral infections.
Claims35
A polynucleotide, encoding a fusion protein comprising (a) an polypeptide immunogen, (b) a self-assembling nanoparticle subunit, and (c) a locking domain subunit that comprises the amino acid sequence set forth in SEQ ID NO:2, or a conservatively modified variant thereof.
Dependencies are inferred from the claim text.