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US 12,447,202 B2Granted
Arthrospira platensis oral vaccine delivery platform
AssigneeLumen Bioscience, Inc.
InventorsJames Roberts, Michael A. Tasch, Tracy Saveria
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Abstract
The present disclosure provides oral antigenic compositions comprising a recombinant Spirulina comprising at least one exogenous antigenic epitope. Oral antigenic compositions of the present disclosure can be used as vaccines. Oral antigenic compositions of the present disclosure can be used to induce a protective immune response to infectious microorganism, tumor antigens, or self-antigens.
Claims12
An oral antigenic composition comprising:
- a recombinant Spirulina, wherein the recombinant Spirulina comprises an exogenous nucleic acid sequence, encoding:
- a chimeric protein comprising an antigenic epitope translationally fused to a viral protein or a virus-like particle (VLP)-forming protein wherein the exogenous nucleic acid sequence is stably integrated into an endogenous locus of the Spirulina;
- and
- one or more pharmaceutically acceptable excipients.
1 more element
Dependencies are inferred from the claim text.