Polymer lung surfactants
AssigneePurdue Research Foundation
InventorsYou-Yeon Won, Hyun Chang Kim
Life of this patent
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Abstract
Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.
Claims10
A method for treating a subject who has been exposed to risks of respiratory distress syndrome (RDS), the method comprising:
- administering to the subject a therapeutically effective amount of a polymer lung surfactant composition to the lungs of the subject in the form of an aqueous solution via instillation or in the form of liquid drop or dried powder aerosols,
- wherein:
- the polymer lung surfactant composition comprises a synthetic biocompatible amphiphilic block copolymer, wherein the hydrophilic, water soluble, block comprises a monomer selected from the group consisting of ethylene glycol (EG), ethylene oxide (EO), vinyl alcohol (VA), and alkyl oxazoline (OZ), wherein the hydrophobic, water-insoluble, block comprises a monomer selected from the group consisting of lactic acid or lactide (LA), glycolic acid or glycolide (GA), caprolactone (CL), styrene (S), methacrylate (MA), acrylate (Ac), butadiene (BD), and isoprene (IP);
- and
- the polymer lung surfactant composition forms stable micelles in aqueous solution.
Dependencies are inferred from the claim text.