Back to results
US 12,447,158 B2Granted
Liquid polymer delivery system for extended administration of drugs
AssigneeTolmar International Limited
InventorsJohn Milton Downing, Vipin Saxena, John Middleton
Life of this patent
Estimating the term…
Abstract
Liquid polymer pharmaceutical compositions with a biodegradable liquid polyester that has a carboxylic acid end group, a biocompatible solvent, and an active pharmaceutical agent are useful for administration into the body to provide extended long term release of the drug.
Claims19
A method for treating a disease in a subject in need thereof, comprising administering into the body of the subject an extended release pharmaceutical composition comprising:
- a biodegradable liquid polyester having a carboxylic acid end group;
- a biocompatible organic solvent or combination of solvents;
- and
- an active pharmaceutical agent,
- wherein:
- the extended release pharmaceutical composition is formulated to release the active pharmaceutical agent for a period of one month or greater;
- the extended release pharmaceutical composition is free of a polyester without a carboxylic acid end group;
- and
- the biodegradable liquid polyester comprises lactide residues and monomer residues selected from the group consisting of caprolactone, trimethylene carbonate, and combinations thereof.
6 more elements
Dependencies are inferred from the claim text.