Multi-functional analgesic-releasing wound dressing

A method of treating pain associated with a partial thickness dermal injury, the method comprising:

• providing a wound dressing, wherein the wound dressing consists of a single, substantially homogenous layer the wound dressing including:
• a porous biosynthetic polymer film comprising a poly (lactide-co-caprolactone) copolymer;
• and
• a local analgesic impregnated within the porous biosynthetic polymer film, wherein the wound dressing provides sustained release of the local analgesic while reducing pain over a sustained period of time of at least 1 day;
• wherein the wound dressing remains in place over the partial thickness dermal injury for a full duration of healing thereof, without removal of the wound dressing for any wound dressing changes, said full duration of healing being about 14 days, wherein the wound dressing releases a burst of at least 60% of the local analgesic over days 1-3 after application over the partial thickness dermal injury, followed by a sustained tapered release from days 4-7 after application, wherein 70-90% of a volume of the wound dressing comprises pores, wherein the wound dressing falls off naturally within 20 days, and wherein polymer weight loss and loss of mechanical properties of the wound dressing is less than 10% within the full duration of healing.

An analgesic-releasing wound dressing comprising:

• a porous biosynthetic polymer film;
• and
• a local analgesic impregnated within the porous biosynthetic polymer film;
• wherein:
• the wound dressing provides sustained release of the local analgesic over a period of at least 1 day, with a burst phase where at least 60% of total analgesic is released within 1-3 days,
• the local analgesic is loaded into the porous biosynthetic polymer film in an amount from 5% to 20% relative to the porous biosynthetic polymer film,
• the analgesic-releasing wound dressing consists of a single, substantially homogenous layer,
• the wound dressing has a thickness of at least 200 μm, and up to 2 mm,
• 70-90% of a volume of the wound dressing comprises pores,
• the wound dressing provides protection for at least 10 days, but debriding or falling off naturally within 20 days when positioned over a partial thickness dermal injury of a patient, and
• polymer weight loss and loss of mechanical properties of the wound dressing is less than 10% within a full duration of healing.