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US 12,446,802 B2Granted
Diffusion layer for an enzymatic in-vivo sensor
AssigneeRoche Diabetes Care, Inc.
InventorsGregor Ocvirk, Angelika Fuerst, Alexander Steck, Juergen Woehrle
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Abstract
The present disclosure relates to an electrode system for measuring the concentration of an analyte under in-vivo conditions, comprising an electrode with immobilized enzyme molecules and a diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules.
Claims16
An electrode system for measuring the concentration of an analyte under in-vivo conditions, comprising:
- an electrode having immobilized enzyme molecules and a diffusion barrier configured to control diffusion of the analyte from the exterior of the electrode system to the enzyme molecules;
- the diffusion barrier comprising a block copolymer having from 75 to 95 mol % of a 2-hydroxyethyl methacrylate (HEMA) block and from 5 to 25 mol % of a hydrophobic block of n-butyl acrylate (n-BuA) or ethyl acrylate (EA), based on the total amount (mol) of the block copolymer in a dry state;
- wherein the glass transition temperature of the hydrophobic block of the n-BuA or EA is in the range of about −80° C. and about 0° C.;
- and
- wherein subjecting a sensor having the electrode system to a 1 mm bending radius avoids indicia of Newton's Rings and/or a sensor having the electrode system has a sensitivity in the range of 1 to 1.5 nA/mM analyte.
2 more elements
Dependencies are inferred from the claim text.