Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs

A system for physiologic regulation of an extracorporeal organ, tissue or bioengineered graft via cross-circulation with a host organism, comprising

• an extracorporeal organ chamber for containing and supporting the extracorporeal organ, tissue or bioengineered graft, wherein the chamber comprises a time- and temperature-controlled humidifier that directs a misting spray onto the organ, tissue or bioengineered graft and into the chamber to maintain a humid environment within the chamber;
• and
• an extracorporeal cross-circulation circuit for connecting the extracorporeal organ, tissue or bioengineered graft with a host organism for cross-circulation of blood or plasma, which circuit comprises:
• fluid conduits providing flow of the blood or plasma between a vascular system of the host organism to vasculature of the extracorporeal organ, tissue or bioengineered graft;
• wherein a first fluid conduit for connecting the host organism to the extracorporeal organ comprises thereon a circulating pump which pumps blood through a circuit which splits to return blood cells directly back to a blood vessel of the host organism and plasma to the extracorporeal organ, and wherein the first fluid conduit comprises an oxygenator.