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US 12,444,478 B2Granted
Noninvasive molecular clock for fetal development predicts gestational age and preterm delivery
AssigneesCZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior University, Statens Serum Institut
InventorsMira N. Moufarrej, Thuy T. M. Ngo, Joan Camunas-Soler, Mads Melbye, Stephen R. Quake
Life of this patent
Estimating the term…
Abstract
The invention is directed to methods of identifying woman is risk for preterm delivery. In some aspects, the methods include quantitating one or more placental or fetal-tissue specific genes in a biological sample from the woman.
Claims11
A method for treating a pregnant subject for elevated risk of having preterm delivery, comprising:
- (a) assaying a maternal sample obtained or derived from the pregnant subject to determine an expression profile of a panel of genes, wherein the panel of genes comprises three or more genes selected from the group consisting of CLCN3, DAPP1, POLE2, PPBP, LYPLAL1, MAP3K7CL, MOB1B, RAB27B, RGS18, and TBC1D15;
- (b) computer processing the expression profile determined in (a) (i) against reference expression levels of the panel of genes or (ii) with a trained machine learning model;
- (c) determining, based at least in part on the computer processing in (b), that the pregnant subject has an elevated risk of having the preterm delivery;
- and
- (d) administering to the pregnant subject a therapeutic intervention for the elevated risk of having the preterm delivery, wherein the therapeutic intervention is selected from the group consisting of a progesterone, an antibiotic, a cervical cerclage, a cervical pessary, a folate supplement, and an omega-3 fatty acid supplement.
2 more elements
Dependencies are inferred from the claim text.