Preservative solution for heme protein, and method for stabilizing heme protein
AssigneeEiken Kagaku Kabushiki Kaisha
InventorsKozue Sakata, Shin Sugo, Ryota Yasui
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Abstract
An object of the present invention is to provide a novel preservative solution for a heme protein and a method for stabilizing a heme protein, which are effective against denaturation or degradation of a heme protein, and the present invention specifically relates to a preservative solution for a heme protein comprising a disulfonic acid or a salt thereof, and a method for stabilizing a heme protein, which involves bringing a disulfonic acid or a salt thereof into coexistence in a sample comprising a heme protein.
Claims9
A preservative solution for a heme protein, comprising a disulfonic acid or a salt thereof and a heme protein,
- wherein the disulfonic acid or a salt thereof is at least one selected from the group consisting of methanedisulfonic acid, ethanedisulfonic acid, butanedisulfonic acid, and a salt thereof;
- and
- wherein the heme protein is selected from the group consisting of hemoglobin, myoglobin, and catalase.
A preservative solution for a heme protein comprising a disulfonic acid or a salt thereof, N-(2-hydroxyethyl)piperazine-N′-ethanesulfonic acid (HEPES) and a heme protein, wherein:
- the disulfonic acid consists of an open chain hydrocarbon group with two sulfone groups or salt thereof, and the open chain hydrocarbon group is a branched or linear hydrocarbon group, does not have a cyclic hydrocarbon group, and the main chain of the branched open chain hydrocarbon group or the linear open chain hydrocarbon group has any one of 1 to 10 carbon atoms;
- and wherein the heme protein is selected from the group consisting of hemoglobin, myoglobin, and catalase.
Dependencies are inferred from the claim text.