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US 12,442,043 B2Granted
Detecting ovarian cancer
AssigneesMayo Foundation for Medical Education and Research, Exact Sciences Corporation
InventorsWilliam R. Taylor, John B. Kisiel, Douglas W. Mahoney, David A. Ahlquist, Hatim T. Allawi, Michael W. Kaiser
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Abstract
Provided herein is technology for ovarian cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of ovarian cancer and sub-types of ovarian cancer (e.g., clear cell ovarian cancer, endometrioid ovarian cancer, mucinous ovarian cancer, serous ovarian cancer).
Claims13
A method comprising:
- treating genomic DNA from a sample from a subject having or suspected of having ovarian cancer with a reagent that modifies DNA in a methylation-specific manner;
- amplifying the treated genomic DNA using a set of primers specific for each of CDO1 and SIM2;
- and
- determining a methylation level of at least one differentially methylated region (DMR) in each of CDO1 and SIM2 using polymerase chain reaction (PCR), nucleic acid sequencing, mass spectrometry, restriction enzyme analysis, mass-based separation, and/or target capture.
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Dependencies are inferred from the claim text.