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US 12,442,027 B2Granted
Method of reducing aromatic nitro compounds
AssigneeAmgen Inc.
InventorsSerena Bisagni, Amin Bornadel, Beatriz Dominguez, Jacques Lepaih, Steven M. Mennen, Ahir Pushpanath, Iustina Slabu, Jason Tedrow, Simon J. Hedley
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Abstract
A method for reducing a substrate selected from 2-methyl-5-nitropyridine and methyl 4-(2-fluoro-3-nitrobenzyl)piperazine-1-carboxylate is provided catalysed by a nitroreductase and a disproportionation agent.
Claims15
A method of reducing an aromatic nitro compound comprising the step of:
- (i) contacting an aromatic nitro compound with a catalyst at ambient temperature and pressure,
- wherein, the catalyst comprises:
- (a) a disproportionation agent;
- and
- (b) a nitroreductase comprising the amino acid sequence of SEQ ID NO:1 [NR-4], SEQ ID NO:2 [NR-14], SEQ ID NO:3 [NR-17] or SEQ ID NO:
- 6 [NR-24], and
- wherein the aromatic nitro compound is 2-methyl-5-nitropyridine and the conversion of the aromatic nitro compound is greater than 90%.
4 more elements
Dependencies are inferred from the claim text.