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US 12,441,815 B2Granted
Compositions and methods for diagnosis of cardiovascular disease
AssigneeThe Regents of the University of California
InventorsYury Miller, Ayelet Gonen, Sotirios Tsimikas, Joseph L. Witztum
Life of this patent
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Abstract
Provided herein are new diagnostic biomarkers for cardiovascular disease, antibodies for detecting said diagnostic biomarkers, and immunoassays, imaging agents, and therapeutics based therefrom.
Claims16
An isolated antibody or antibody fragment comprising a variable heavy chain (VH) domain and a variable light chain (VL) domain;
- wherein the VH domain comprises SEQ ID NO:2;
- and
- wherein the VL domain comprises SEQ ID NO:4,
- wherein the antibody or antibody fragment binds to an oxidized cholesteryl ester (OxCE) of arachidonic acid.
1 more element
A single chain variable fragment (“scFv”) that comprises a VH domain,
- wherein the VH domain comprises SEQ ID NO:2;
- and
- wherein the VL domain comprises SEQ ID NO:4,
- wherein the scFv binds to an oxidized cholesteryl ester (OxCE) of arachidonic acid.
1 more element
Dependencies are inferred from the claim text.