Pathogen binding proteins

An isolated protein comprising

• a first peptide;
• a second peptide;
• and
• a linker,
• wherein said first and said second peptides bind at least one pathogen surface component and/or at least one molecule produced by a pathogen,
• wherein:
• said first peptide is a single domain antibody comprising three complementarity determining regions CDR1, CDR2 and CDR3, wherein:
• CDR1 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 27,
• CDR2 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 29, and
• CDR3 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 31, and
• said second peptide is a single domain antibody comprising three complementarity determining regions CDR1, CDR2 and CDR3, wherein:
• CDR1 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 27,
• CDR2 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 29, and
• CDR3 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 31, and
• wherein said protein comprises an amino acid sequence according to SEQ ID NO:15 or an amino acid sequence having at least 90% identity to SEQ ID NO:15;
• or
• said first peptide is a single domain antibody comprising three complementarity determining regions CDR1, CDR2, and CDR3, wherein:
• CDR1 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 28,
• CDR2 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 30, and
• CDR3 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 32, and
• said second peptide is a single domain antibody comprising three complementarity determining regions CDR1, CDR2, and CDR3, wherein:
• CDR1 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 28,
• CDR2 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 30, and
• CDR3 has an amino acid sequence comprising an amino acid sequence of SEQ ID NO:
• 32, and
• wherein said protein comprises an amino acid sequence according to SEQ ID NO:13 or an amino acid sequence having at least 90% identity to SEQ ID NO:13;
• or
• said first peptide is a single domain antibody comprising an amino acid sequence according to SEQ ID NO:
• 5 or an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
• 5, wherein any sequence variance is outside the CDRs;
• said second peptide is a single domain antibody comprising an amino acid sequence according to SEQ ID NO:
• 5 or an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
• 5, wherein any sequence variance is outside the CDRs;
• and
• wherein said protein comprises an amino acid sequence according to SEQ ID NO:14 or an amino acid sequence having at least 90% identity to SEQ ID NO:14.