Molecular guide system peptides and uses thereof
AssigneeSRI International
InventorsKathlynn C. Brown, Nathan Collins, Shunzi “Susan” Li, Curtis Allred, Keen Chung, Michael McGuire
Life of this patent
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Abstract
Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.
Claims14
A composition comprising an antibody conjugated to a molecular guidance system (MGS) peptide, directly or via a linker, wherein the MGS peptide is selected from the group consisting of:
- YAAWPASGAWT (SEQ ID NO:
- 6), D-Leu-RGDLATLRQL (SEQ ID NO:
- 8), LQWRRNFGVWARYRL (SEQ ID NO:
- 31), KQYATPRVFWT (SEQ ID NO:
- 33), CH3CO-YAAWPASGAWT-PEG11-C-NH2 (SEQ ID NO:
- 71), CH3CO-LQWRRNFGVWARYRL -PEG11-C-NH2 (SEQ ID NO:
- 72), CH3CO-RGDLATLRQL-PEG11-YC-NH2 (SEQ ID NO:
- 73), CH3CO-D-Leu-RGDLATLRQL-PEG11-YC-NH2 (SEQ ID NO:
- 74), CH3CO-FHAVPQSFYT (SEQ ID NO:
- 80), CH3CO-D-Leu-RGDLATLRQL (SEQ ID NO:
- 81), CH3CO -YAAWPASGAWT (SEQ ID NO:
- 82), CH3CO-KQYATPRVFWT (SEQ ID NO:
- 84), and CH3CO-LQWRRNFGVWARYRL (SEQ ID NO:
- 85).
A molecular guidance system (MGS) peptide selected from the group consisting of:
- D-Leu-RGDLATLRQL (SEQ ID NO:
- 8), LQWRRNFGVWARYRL (SEQ ID NO:
- 31), CH3CO-YAAWPASGAWT-PEG11-C-NH2 (SEQ ID NO:
- 71), CH3CO-LQWRRNFGVWARYRL-PEG11-C-NH2 (SEQ ID NO:
- 72), and CH3CO-LQWRRNFGVWARYRL (SEQ ID NO:
- 85).
Dependencies are inferred from the claim text.