Hangtaimycin derivatives and their preparation methods and application
AssigneeWuhan University
InventorsYuhui Sun, Minghe Luo, Yanqin Li, Jin Xiang, Zixin Deng
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Abstract
The embodiment of the present invention discloses Hangtaimycin derivatives and their preparation and application. Hangtaimycin derivatives are obtained by fermentation of Streptomyces spectabilis CCTCC M2017417 and its genetically knockout mutant strain in SFMR medium, with further isolation, purification, and alcoholysis. Through screening, Hangtaimycin derivatives showed excellent anti-inflammatory and analgesic, anti-tumor, liver injury protection, cell membrane protection, and drug addiction prevention activities, providing new drug leads for developing related drugs.
Claims6
A Hangtaimycin derivative, comprising Hangtaimycin A or Hangtaimycin B, wherein the Hangtaimycin A and the Hangtaimycin B are alcoholysis derivatives, whose chemical structures are as following:
Dependencies are inferred from the claim text.